millions treated for hypothyroidism at risk for lung cancer

In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to 'replacement' therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. View the data on our Hypothyroidism Research page. However, I'm learning from science writer friends, researchers, and medical professionals that (1) some studies are better designed and carried out than others, and (2) some journalists are more careful about drawing conclusions and writing sensational headlines than others. However, the study looked at the incrase of ALL lung cancers, not SCLC, so that data does not correlate with this study. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. PMID: 15253676. Endocrinol. What I am personally saying issince I personally have a disease that may kill me, I sure as heck have every right to find out ALL I can about it. View the data on GreenMedInfos Hypothyroidism Research page. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: "[I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. It took over five years before the someone figured out my ongoing symptoms were due to hypothyroidism. Methods: The study group included 35 patients (15 women, 20 men, 65.8 7.1 years) with NSCLC in stage IIIB (n = 16, 45.7%) and IV (n = 19,54.3%) who were treated with nivolumab. [15] [16] There is also the more logical option of support the body's thyroid-hormone producing capabilities using the thyroxine precursor L-tyrosine, a basic amino acid with a relatively high margin of safety. Also, what is oxidised stress??? I have been reading Izabella Wentz. I don't think so. Privacy Policy. Just for entertainment value take a look at some more dodgy correlations : I rather liked the correlation between consumption of orange marmalade and birth rate - in the years after the second world war if I remember correctly. (31) 3351-3382 | 3351-3272 | 3351-3141 | 3351-3371. location of blind frog ranch associe-se. [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. Why not simply call it selenium deficiency? Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. Oops, I just saw that I posted the same article. The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore 'back up' causing excessive T4 activity, i.e. They found no significant correlation between T4 sales and breast, colorectal and gastric cancers, but did find a significant correlation for lung cancer (p < 0.05) corrected for smoking and age. Hypothyroidism can cause depression and, without treatment, the symptoms intensify and directly affect the mental state. The article also stresses that too many people are being given the diagnosis of either hypo or hyperthyroidism. Intuition and Trust: a Personal Journey Through Ancient Pathways, Meditation, Yoga, Grounding & Mindfulness, Levothyroxine and lung cancer in females: the importance of oxidative stress, 2013 announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs, Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). It does not necessarily imply one thing caused the other. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: Recently T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. Note: Only a member of this blog may post a comment. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. ", That study is like a fishing expedition. There are many links attached. Iodine - and the lack of it - is implicated in breast cancer, after all. In my opinion, the science of the study doesn't support the conclusion. This relatively symptom-free reservoir of 'hypothyroid' cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM. Obesity epidemic caused by EMF exposures in the ho War on Health - The FDA's Cult of Tyranny. Respiratory system Hypothyroidism weakens the respiratory muscles and decreases lung function. [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. There is evidence T4 makes cancer more agressive, so although it increases the risk of cancer the mortality risk is higher. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. This website is for information purposes only. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' Eventually, the decline in thyroid hormone production can result in any of the following: Fatigue and sluggishness. It looks at correlations, as if they had any merit on their own. Sin un requerimiento, el cumplimiento voluntario por parte de tu Proveedor de servicios de Internet, o los registros adicionales de un tercero, la informacin almacenada o recuperada slo para este propsito no se puede utilizar para identificarte. Medical Authoritys System Kills: FDA-Approved Dru Cognitive Impairment, Memory Loss and Alzheimer's Soy Lecithin: How It Negatively Affects Your Healt Cannabis Oil Cures Cancer -Lincoln Horsley's Story New Information Dissolves Illusions About Vaccines Grounding Helps Thin Dangerously Thick Blood and F Tart Cherries Relieve Osteoarthritis Pain, Lieberman's Massive Connections To Big Pharma, Utopian 'Harvest Your Own' Groceries Coming Up. Here members can share stories, find important information and learn from the experiences of others like themselves. Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. [13] Hollowell JG, Staehling NW, Flanders WD, et al. Just another excuse for keeping us on doses that are too low. This is a horrible disease that ravages the body. Endocrinology 1985, 117:12011208. Even in the mildest form, hypothyroidism affects the heart. Si as lo deseas puedes revisar el resto de nuestros contenidos para encontrar lo que buscabas o directamente utilizar nuestro buscador. Tokushima J Exp Med 1991, 38:2535. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. Forgot account? The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. Increased sensitivity to cold. As a person with Graves Disease, I underwent 6 cycles of radio-ablation using i 131 to 'fry' my thyroid gland as surgery was deemed too risky due to the vascularity and size of my gland. 2002 Feb ;25(2):106-9. A distorted idea of human nature is sold when people are treated as "the market. I posted it to see what anyone had to add. Endocrinology 2008, 149:22412250. En 3 minutos recibirs en tu email COMPLETAMENTE GRATIS todo lo que necesitas para aumentar las ventas de tu empresa. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. Join the forum, it's quick and easy . Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. millions treated for hypothyroidism at risk for lung cancer. Clin Cancer Res 2011, 30:77. With the recent announcement by a National Cancer Institute commissioned expert panel that a variety of so-called 'indolent' neoplasms such as ductal carcinoma in situ (DCIS) and high-grade prostatic intraepithelial neoplasia (HGPIN), formerly understood to be forms of breast and prostate cancers, respectively, should be renamed to reflect their intrinsic benignity, a veritable sea change is occurring within the conventional medical establishment. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. Baked or Fried avocado fries [Vegetarian]. The authors expanded on their findings further: However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. I have always found this condition a riddle. Post by D.ap Tue Feb 21, 2017 6:40 pm "A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and . http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-l Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, Iodine Supplementation Support by VWT Team. [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5'-monodeiodination (DI). You must log in or register to reply here. Hypothyroidism results from low levels of thyroid hormone with varied etiology and manifestations. Article published in Wakeup-World.Com. Join the Patient & Caregiver Network. An Italian study published in the journalReproductive Biology and Endocrinology,titled Levothyroxine and lung cancer in females: the importance of oxidative stress, has raised a concerning possibility: levothyroxine (T4), one of the worlds most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. I wonder if only t3 treatments are preferable than t4 and t3 ? Overtreatment, of course, is the hallmark danger of overdiagnosis. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. [8] van Doorn J, Roelfsema F, van der Heide D: Concentration of thyroxine and 3,5,3'-triiodotyronine in several rat tissue in vivo: the effect of hypothyroidism. I honestly do not know. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. Levothyroxine is a widely prescribed medication for the treatment of an underactive thyroid. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. If You Don't Want Older Bones, Don't Be Low In Vit Background Mortality Rate for Vaccines, or Pseudo Everything You Ever Wanted to Know About Black Seeds. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. Untreated hypothyroidism increases morbidity and mortality. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. Monaldi Arch Chest Dis 2003, 59:140145. However, they pointed out that the opposite was actually described, and that hypothyroidism reduces the aggressiveness of some cancers because of the presence of thyroid hormone receptors on cancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers.[1]. and our Scan this QR code to download the app now. [8] van Doorn J, Roelfsema F, van der Heide D: Concentration of thyroxine and 3,5,3-triiodotyronine in several rat tissue in vivo: the effect of hypothyroidism. Breast cancer has surpassed lung cancer as the most commonly diagnosed cancer worldwide, according to GLOBOCAN. I have no further scientific evidence. Metab.87 (2): 48999. Another recently approved drug is tepotinib (Tepmetko). [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. is the fiec part of the evangelical alliance; townhomes in avalon park; 8 ft windmill parts; why is my cash and sweep vehicle negative; nordstrom rack return policy worn shoes Non-ASPS articles which could be relevant. I'm just saying the evidence presented in this article isn't very strong, and more study is needed to show Synthroid causes lung cancer. Yet Another Frankenfood Pandoras Box: the Majorit How Medical Science Proves that Black Is White. I do not believe in random events, of nature or otherwise. Lung cancer survivors support group and discussion community, http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-lung-cancers?utm_source=www.GreenMedInfo.com&utm_campaign=2189ddd3c1-Greenmedinfo&utm_medium=email&utm_term=0_193c8492fb-2189ddd3c1-87046221. Physician/Author on Facebook. Different strokes for different folks for sure! I invite those interested to read it and perhaps we can have a discussion on this study. Is Drug-Based Medicine a Form of Human Sacrifice? Link posted. I have so many women friends and family members who have recently been diagnosed with hypothyroidism and their doctors put them all on Synthyroid. Angiology 2000, 51:S65S68. If it's high, the test is done again, along with a blood test for the thyroid hormone T-4. As a never smoker I truly wish I smoked so I could just say that's why I got this. Post The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. To investigate the magnitude of the possible association between levothyroxine use and cancer risk, this retrospective c The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. It's usually based on the results of blood tests. [5]Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5 deiodinase in lung cancer with peripheral lung tissues. It was the therapist that I went to that referred me to a specialist who ran the correct tests. Acta Endocrinol 1988, 118:460464. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. elevated TSH, without actually improving the overall physiological situation, nor the patient's subjective experience of well being. Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). Epub 2013 Mar 28. I will respond more later onBut I will briefly say I was on Synthyroid from 1993 to 2011. Diagnosed 1/12 with lung cancer out of the blue. The American Lung Association connects patients, families, friends and caregivers for support and inspiration as they face lung cancer. It is worth reading. [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. In the United States, autoimmune thyroid disease (Hashimoto thyroiditis) is the most common cause of hypothyroidism, but globally lack of iodine in the diet is the most common cause. Perhaps she and I could co-author? This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic 'self-fulfilling prophecy' if you will. They compared sale of, "However, the impression we get from our experience, Health, Studies, Supps & Pharmaceuticals. In my view the paper isn't worth the pixels used to display it on a screen. Angiology 2000, 51:S65S68. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? Overtreatment, of course, is the hallmark danger of overdiagnosis. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. El almacenamiento o acceso tcnico que es utilizado exclusivamente con fines estadsticos. She wrote about a product called Thyrtophin PMG. May be of interest: Study: Millions Treated for Hypothyroidism At Risk for, Non-small cell lung cancer - Adenocarcinoma, Non-small cell lung cancer - Squamous cell, Top 5 Questions to Ask Your Lung Cancer Doctor, Patient & Caregiver Network Member Resources, Not A Member Yet? The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. Patients with incomplete information (n = 127), preexisting hypothyroidism or levothyroxine replacement before initiation of ICI therapy (n = 11), or other factors known to contribute to thyroid dysfunction after immunotherapy (n = 17) were excluded (Fig. The increasingly global medical-industrial complex has begun to co-opt all aspects of the natural human bodily life cycle, and all the organ systems within it, as potential targets of medical surveillance and intervention, not excluding the human thyroid. Nah, I would give this much credence. This discussion has been closed to comments. LifeGivingStore.comRed Light Therapy - Hydrogen Water Generators - Cascara Sagrada - Vitamins, Minerals & Amino Acid Supplements - Cocoa Products - Handcrafted Soaps - Grass Fed Organs & Glandulars - Nano Soma. Hashimoto's disease progresses slowly over the years. [4], DI activity in lung cancer was found to be lower than in peripheral lung tissue.[5]. Are you sure you want to block this member? When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. Maybe because they "treat" only with T4 and not T3? The authors did not study whether individuals who took Synthroid actually developed lung cancer later in life. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low . I have posted the link now. florence nightingale concept 2 via de boleto Acta Endocrinol 1988, 118:460464. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. Compared to patients without hypothyroidism, those with a high TSH level before hospitalization stayed in the hospital 1.2 days longer and had a 49% higher risk of 30-day readmission and a 43% . A place for patients and relatives. In the U.S., the overall five-year survival rate for patients diagnosed with lung cancer is 25%, which is a 21% improvement over the . rocket fuel, pesticides, fluoride, which induce low thyroid function. Data sources: The Medline and Cochrane Library electronic databases . Currently, the best practical approach is to base treatment decisions on the degree of TSH elevation, thyroid autoimmunity, and associated comorbidities. Just go on one of the thyroid sites and read the stories. Is that what releases free radicals? Whether it should be treated remains controversial. Researchers are currently studying. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Once I got on the medication, the symptoms disappeared. Gestionar el consentimiento de las cookies. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: [I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. Or, simply look at what the young-adult, T-score based definition of osteoporosis and osteopenia has done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a 'TSH suppressor.' International Journal of Human Nutrition and Functional Medicine, Black Seed May Treat Hypothyroidism (Hashimotos Disease), Clinical Trial Reveals, Wi-Fi Devices Increase Mercury Release From Dental Amalgams, Participating in Drum Circles Improves Health and Quality of Life in Parkinsons Patients (Study), Acupuncture Beats Injected Morphine for Pain: Groundbreaking Study, Mammography Is Harmful and Should Be Abandoned, Scientific Review Concludes, Killer Germs Obliterated by Medicinal Smoke Smudging, Study Reveals, Turmerics Smart Kill Properties Put Chemo & Radiation To Shame, Beet Juice Boosts Cognitive Function In One Dose, 13 Evidence-Based Medicinal Properties of Coconut Oil, Group Drumming Better Than Prozac, Study Suggests, 25 Cancer Stem-Cell Killing Foods That Are Smarter Than Chemo and Radiation, Ibuprofen Can Stop Your Heart 31% Increase in Cardiac Arrest Risk, Conscious Shopping Offering Conscious Products for Conscious People, Uncovering The Truths And Myths About 3 Superstar Herbs, Living Past 100: The Okinawan Diet and Blue Zone Centenarians, Repairs DNA and Rejuvenates Your Cells While You Relax, Why Daily Greens are the Real Fountain of Youth, T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. 2004 Jun;9(2):157-79. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the low thyroid, why call chemical poisoning hypothyroidism?

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millions treated for hypothyroidism at risk for lung cancer

millions treated for hypothyroidism at risk for lung cancerwhat happened to kenny beck wxii

In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to 'replacement' therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. View the data on our Hypothyroidism Research page. However, I'm learning from science writer friends, researchers, and medical professionals that (1) some studies are better designed and carried out than others, and (2) some journalists are more careful about drawing conclusions and writing sensational headlines than others. However, the study looked at the incrase of ALL lung cancers, not SCLC, so that data does not correlate with this study. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. PMID: 15253676. Endocrinol. What I am personally saying issince I personally have a disease that may kill me, I sure as heck have every right to find out ALL I can about it. View the data on GreenMedInfos Hypothyroidism Research page. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: "[I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. It took over five years before the someone figured out my ongoing symptoms were due to hypothyroidism. Methods: The study group included 35 patients (15 women, 20 men, 65.8 7.1 years) with NSCLC in stage IIIB (n = 16, 45.7%) and IV (n = 19,54.3%) who were treated with nivolumab. [15] [16] There is also the more logical option of support the body's thyroid-hormone producing capabilities using the thyroxine precursor L-tyrosine, a basic amino acid with a relatively high margin of safety. Also, what is oxidised stress??? I have been reading Izabella Wentz. I don't think so. Privacy Policy. Just for entertainment value take a look at some more dodgy correlations : I rather liked the correlation between consumption of orange marmalade and birth rate - in the years after the second world war if I remember correctly. (31) 3351-3382 | 3351-3272 | 3351-3141 | 3351-3371. location of blind frog ranch associe-se. [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. Why not simply call it selenium deficiency? Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. Oops, I just saw that I posted the same article. The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore 'back up' causing excessive T4 activity, i.e. They found no significant correlation between T4 sales and breast, colorectal and gastric cancers, but did find a significant correlation for lung cancer (p < 0.05) corrected for smoking and age. Hypothyroidism can cause depression and, without treatment, the symptoms intensify and directly affect the mental state. The article also stresses that too many people are being given the diagnosis of either hypo or hyperthyroidism. Intuition and Trust: a Personal Journey Through Ancient Pathways, Meditation, Yoga, Grounding & Mindfulness, Levothyroxine and lung cancer in females: the importance of oxidative stress, 2013 announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs, Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). It does not necessarily imply one thing caused the other. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: Recently T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. Note: Only a member of this blog may post a comment. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. ", That study is like a fishing expedition. There are many links attached. Iodine - and the lack of it - is implicated in breast cancer, after all. In my opinion, the science of the study doesn't support the conclusion. This relatively symptom-free reservoir of 'hypothyroid' cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM. Obesity epidemic caused by EMF exposures in the ho War on Health - The FDA's Cult of Tyranny. Respiratory system Hypothyroidism weakens the respiratory muscles and decreases lung function. [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. There is evidence T4 makes cancer more agressive, so although it increases the risk of cancer the mortality risk is higher. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. This website is for information purposes only. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' Eventually, the decline in thyroid hormone production can result in any of the following: Fatigue and sluggishness. It looks at correlations, as if they had any merit on their own. Sin un requerimiento, el cumplimiento voluntario por parte de tu Proveedor de servicios de Internet, o los registros adicionales de un tercero, la informacin almacenada o recuperada slo para este propsito no se puede utilizar para identificarte. Medical Authoritys System Kills: FDA-Approved Dru Cognitive Impairment, Memory Loss and Alzheimer's Soy Lecithin: How It Negatively Affects Your Healt Cannabis Oil Cures Cancer -Lincoln Horsley's Story New Information Dissolves Illusions About Vaccines Grounding Helps Thin Dangerously Thick Blood and F Tart Cherries Relieve Osteoarthritis Pain, Lieberman's Massive Connections To Big Pharma, Utopian 'Harvest Your Own' Groceries Coming Up. Here members can share stories, find important information and learn from the experiences of others like themselves. Study: Millions Treated for Hypothyroidism At Risk of Lung Cancer. [13] Hollowell JG, Staehling NW, Flanders WD, et al. Just another excuse for keeping us on doses that are too low. This is a horrible disease that ravages the body. Endocrinology 1985, 117:12011208. Even in the mildest form, hypothyroidism affects the heart. Si as lo deseas puedes revisar el resto de nuestros contenidos para encontrar lo que buscabas o directamente utilizar nuestro buscador. Tokushima J Exp Med 1991, 38:2535. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. Forgot account? The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. Increased sensitivity to cold. As a person with Graves Disease, I underwent 6 cycles of radio-ablation using i 131 to 'fry' my thyroid gland as surgery was deemed too risky due to the vascularity and size of my gland. 2002 Feb ;25(2):106-9. A distorted idea of human nature is sold when people are treated as "the market. I posted it to see what anyone had to add. Endocrinology 2008, 149:22412250. En 3 minutos recibirs en tu email COMPLETAMENTE GRATIS todo lo que necesitas para aumentar las ventas de tu empresa. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. Join the forum, it's quick and easy . Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. millions treated for hypothyroidism at risk for lung cancer. Clin Cancer Res 2011, 30:77. With the recent announcement by a National Cancer Institute commissioned expert panel that a variety of so-called 'indolent' neoplasms such as ductal carcinoma in situ (DCIS) and high-grade prostatic intraepithelial neoplasia (HGPIN), formerly understood to be forms of breast and prostate cancers, respectively, should be renamed to reflect their intrinsic benignity, a veritable sea change is occurring within the conventional medical establishment. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. Baked or Fried avocado fries [Vegetarian]. The authors expanded on their findings further: However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. I have always found this condition a riddle. Post by D.ap Tue Feb 21, 2017 6:40 pm "A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and . http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-l Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, Iodine Supplementation Support by VWT Team. [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5'-monodeiodination (DI). You must log in or register to reply here. Hypothyroidism results from low levels of thyroid hormone with varied etiology and manifestations. Article published in Wakeup-World.Com. Join the Patient & Caregiver Network. An Italian study published in the journalReproductive Biology and Endocrinology,titled Levothyroxine and lung cancer in females: the importance of oxidative stress, has raised a concerning possibility: levothyroxine (T4), one of the worlds most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. I wonder if only t3 treatments are preferable than t4 and t3 ? Overtreatment, of course, is the hallmark danger of overdiagnosis. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. [8] van Doorn J, Roelfsema F, van der Heide D: Concentration of thyroxine and 3,5,3'-triiodotyronine in several rat tissue in vivo: the effect of hypothyroidism. I honestly do not know. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. Levothyroxine is a widely prescribed medication for the treatment of an underactive thyroid. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. If You Don't Want Older Bones, Don't Be Low In Vit Background Mortality Rate for Vaccines, or Pseudo Everything You Ever Wanted to Know About Black Seeds. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. Untreated hypothyroidism increases morbidity and mortality. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. Monaldi Arch Chest Dis 2003, 59:140145. However, they pointed out that the opposite was actually described, and that hypothyroidism reduces the aggressiveness of some cancers because of the presence of thyroid hormone receptors on cancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers.[1]. and our Scan this QR code to download the app now. [8] van Doorn J, Roelfsema F, van der Heide D: Concentration of thyroxine and 3,5,3-triiodotyronine in several rat tissue in vivo: the effect of hypothyroidism. Breast cancer has surpassed lung cancer as the most commonly diagnosed cancer worldwide, according to GLOBOCAN. I have no further scientific evidence. Metab.87 (2): 48999. Another recently approved drug is tepotinib (Tepmetko). [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. is the fiec part of the evangelical alliance; townhomes in avalon park; 8 ft windmill parts; why is my cash and sweep vehicle negative; nordstrom rack return policy worn shoes Non-ASPS articles which could be relevant. I'm just saying the evidence presented in this article isn't very strong, and more study is needed to show Synthroid causes lung cancer. Yet Another Frankenfood Pandoras Box: the Majorit How Medical Science Proves that Black Is White. I do not believe in random events, of nature or otherwise. Lung cancer survivors support group and discussion community, http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-lung-cancers?utm_source=www.GreenMedInfo.com&utm_campaign=2189ddd3c1-Greenmedinfo&utm_medium=email&utm_term=0_193c8492fb-2189ddd3c1-87046221. Physician/Author on Facebook. Different strokes for different folks for sure! I invite those interested to read it and perhaps we can have a discussion on this study. Is Drug-Based Medicine a Form of Human Sacrifice? Link posted. I have so many women friends and family members who have recently been diagnosed with hypothyroidism and their doctors put them all on Synthyroid. Angiology 2000, 51:S65S68. If it's high, the test is done again, along with a blood test for the thyroid hormone T-4. As a never smoker I truly wish I smoked so I could just say that's why I got this. Post The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. To investigate the magnitude of the possible association between levothyroxine use and cancer risk, this retrospective c The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. It's usually based on the results of blood tests. [5]Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5 deiodinase in lung cancer with peripheral lung tissues. It was the therapist that I went to that referred me to a specialist who ran the correct tests. Acta Endocrinol 1988, 118:460464. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. elevated TSH, without actually improving the overall physiological situation, nor the patient's subjective experience of well being. Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). Epub 2013 Mar 28. I will respond more later onBut I will briefly say I was on Synthyroid from 1993 to 2011. Diagnosed 1/12 with lung cancer out of the blue. The American Lung Association connects patients, families, friends and caregivers for support and inspiration as they face lung cancer. It is worth reading. [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. In the United States, autoimmune thyroid disease (Hashimoto thyroiditis) is the most common cause of hypothyroidism, but globally lack of iodine in the diet is the most common cause. Perhaps she and I could co-author? This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic 'self-fulfilling prophecy' if you will. They compared sale of, "However, the impression we get from our experience, Health, Studies, Supps & Pharmaceuticals. In my view the paper isn't worth the pixels used to display it on a screen. Angiology 2000, 51:S65S68. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? Overtreatment, of course, is the hallmark danger of overdiagnosis. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. El almacenamiento o acceso tcnico que es utilizado exclusivamente con fines estadsticos. She wrote about a product called Thyrtophin PMG. May be of interest: Study: Millions Treated for Hypothyroidism At Risk for, Non-small cell lung cancer - Adenocarcinoma, Non-small cell lung cancer - Squamous cell, Top 5 Questions to Ask Your Lung Cancer Doctor, Patient & Caregiver Network Member Resources, Not A Member Yet? The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. Patients with incomplete information (n = 127), preexisting hypothyroidism or levothyroxine replacement before initiation of ICI therapy (n = 11), or other factors known to contribute to thyroid dysfunction after immunotherapy (n = 17) were excluded (Fig. The increasingly global medical-industrial complex has begun to co-opt all aspects of the natural human bodily life cycle, and all the organ systems within it, as potential targets of medical surveillance and intervention, not excluding the human thyroid. Nah, I would give this much credence. This discussion has been closed to comments. LifeGivingStore.comRed Light Therapy - Hydrogen Water Generators - Cascara Sagrada - Vitamins, Minerals & Amino Acid Supplements - Cocoa Products - Handcrafted Soaps - Grass Fed Organs & Glandulars - Nano Soma. Hashimoto's disease progresses slowly over the years. [4], DI activity in lung cancer was found to be lower than in peripheral lung tissue.[5]. Are you sure you want to block this member? When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. Maybe because they "treat" only with T4 and not T3? The authors did not study whether individuals who took Synthroid actually developed lung cancer later in life. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low . I have posted the link now. florence nightingale concept 2 via de boleto Acta Endocrinol 1988, 118:460464. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. Compared to patients without hypothyroidism, those with a high TSH level before hospitalization stayed in the hospital 1.2 days longer and had a 49% higher risk of 30-day readmission and a 43% . A place for patients and relatives. In the U.S., the overall five-year survival rate for patients diagnosed with lung cancer is 25%, which is a 21% improvement over the . rocket fuel, pesticides, fluoride, which induce low thyroid function. Data sources: The Medline and Cochrane Library electronic databases . Currently, the best practical approach is to base treatment decisions on the degree of TSH elevation, thyroid autoimmunity, and associated comorbidities. Just go on one of the thyroid sites and read the stories. Is that what releases free radicals? Whether it should be treated remains controversial. Researchers are currently studying. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Once I got on the medication, the symptoms disappeared. Gestionar el consentimiento de las cookies. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: [I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. Or, simply look at what the young-adult, T-score based definition of osteoporosis and osteopenia has done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a 'TSH suppressor.' International Journal of Human Nutrition and Functional Medicine, Black Seed May Treat Hypothyroidism (Hashimotos Disease), Clinical Trial Reveals, Wi-Fi Devices Increase Mercury Release From Dental Amalgams, Participating in Drum Circles Improves Health and Quality of Life in Parkinsons Patients (Study), Acupuncture Beats Injected Morphine for Pain: Groundbreaking Study, Mammography Is Harmful and Should Be Abandoned, Scientific Review Concludes, Killer Germs Obliterated by Medicinal Smoke Smudging, Study Reveals, Turmerics Smart Kill Properties Put Chemo & Radiation To Shame, Beet Juice Boosts Cognitive Function In One Dose, 13 Evidence-Based Medicinal Properties of Coconut Oil, Group Drumming Better Than Prozac, Study Suggests, 25 Cancer Stem-Cell Killing Foods That Are Smarter Than Chemo and Radiation, Ibuprofen Can Stop Your Heart 31% Increase in Cardiac Arrest Risk, Conscious Shopping Offering Conscious Products for Conscious People, Uncovering The Truths And Myths About 3 Superstar Herbs, Living Past 100: The Okinawan Diet and Blue Zone Centenarians, Repairs DNA and Rejuvenates Your Cells While You Relax, Why Daily Greens are the Real Fountain of Youth, T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. 2004 Jun;9(2):157-79. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the low thyroid, why call chemical poisoning hypothyroidism? Who Is Running For Governor Of Nebraska 2021, Hcg And Phentermine Together Results, Rush University Human Resources, Articles M

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